Molecular Variants of the EWS-WT1 Gene Fusion in Desmoplastic Small Round Cell Tumor

Abstract excerpt

We report two cases of desmoplastic small round cell tumor (DSRCT) with novel molecular variants of the specific EWS-WT1 gene fusion. This fusion usually encodes a chimeric RNA with an in-frame junction of exon 7 of EWS to exon 8 of WT1. In one variant patient, the EWS-WT1 fusion transcript contained an in-frame junction of exon 9 of EWS to exon 8 of WT1. Moreover, in this patient the tumor arose in the hand, an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac tumors and thrombi
• Share to Histiocytic Disorders and Treatments
• Share to Sarcoma Diagnosis and Treatment