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Article

Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1999

Housley G D, Kanjhan R, Raybould N P, Greenwood D, Salih S G, Järlebark L, Burton L D, Setz V C, Cannell M B, Soeller C, Christie D L, Usami S, Matsubara A, Yoshie H, Ryan A F, Thorne P R

Abstract excerpt

Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-gated ion channels involved in this process were characterized in the guinea pig cochlea. Voltage-clamped hair cells exhibited a P2 receptor pharmacology compatible with the assembly of ATP-gated ion channels from P2X(2) receptor subunits. Reverse transcription-PCR experiments confirmed expression of the P2X(2-1) receptor...

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Identifiers

PMID: 10493739
PMCID: PMC6783052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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