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Article

Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome

23 Nov 1995

Abstract excerpt

BACKGROUND: Increased levels of P-glycoprotein occur in some osteosarcomas. In this study we determined the relation between P-glycoprotein status and outcome in patients with high-grade osteosarcoma. METHODS: P-glycoprotein status was determined immunohistochemically in specimens of osteosarcoma of the extremities (stage II) from 92 patients who were treated with surgery and chemotherapy. The P-glycoprotein...

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PMID: 7477118
DOI: 10.1056/nejm199511233332103

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