Article
Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency.
American journal of medical genetics - 15 Oct 1999
Town T, Abdullah L, Crawford F, Schinka J, Ordorica P I, Francis E, Hughes P, Duara R, Mullan M
Abstract excerpt
Genetic association studies have implicated the TaqI A1 allele of the human dopamine D2 receptor gene (DRD2) as a risk-determining factor for alcohol dependency. However, as alcoholism is a disease of polygenic inheritance, the percentage of overall disease variance explained by the TaqI A1 allele is small. In searching for other genetic loci that may, either alone or in combination with DRD2, enhance prediction...
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