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Article

Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector.

Gene therapy - 1 Feb 2007

Oka K, Belalcazar L M, Dieker C, Nour E A, Nuno-Gonzalez P, Paul A, Cormier S, Shin J-K, Finegold M, Chan L

Abstract excerpt

We examined the efficacy and host response to the adenovirus (Ad)-mediated delivery of human apolipoprotein A-I (APOA1) gene to the liver of APOA1(-/-) mice. Administration of a first-generation vector (FGAd-AI) resulted in a transient appearance of APOA1 in plasma and induced an anti-APOA1 antib...

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Source

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Identifiers

PMID: 16957769
DOI: 10.1038/sj.gt.3302819
PMCID: PMC1780075

Genes

APOA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16957769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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