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Article

AAV-HDV: An Attractive Platform for the In Vivo Study of HDV Biology and the Mechanism of Disease Pathogenesis.

Viruses - 28 Apr 2021

Maestro Sheila, Gómez-Echarte Nahia, Camps Gracián, Usai Carla, Suárez Lester, Vales África, Olagüe Cristina, Aldabe Rafael, González-Aseguinolaza Gloria

Abstract excerpt

Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, but little is known about the molecular mechanisms involved. We have recently developed an HDV mouse model based on the delivery of HDV replication-competent genomes using adeno-associated vectors (AAV), which developed a liver pathology very similar to the human disease and allowed us to perform mechanistic studies. We have...

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Identifiers

PMID: 33925087
DOI: 10.3390/v13050788
PMCID: PMC8145145

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