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A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal

26 Nov 1996

Abstract excerpt

Adenoviruses are attractive vectors for the delivery of foreign genes into mammalian cells for gene therapy. However, current vectors retain many viral genes that, when expressed at low levels, contribute to the induction of a host immune response against transduced cells. We have developed a helper-dependent packaging system for production of vectors that have large regions of the genome deleted. Helper viruses...

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PMID: 8942974
DOI: 10.1073/pnas.93.24.13565

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