Article
Replication of hepatitis C virus in ascitic mononuclear cells with development of distinct viral quasispecies.
The Journal of infectious diseases - 1 Oct 1999
Hsu C W, Yeh C T, Chen P G, Liaw Y F
Abstract excerpt
To investigate whether distinct compositions of viral quasispecies developed in the ascitic fluid of patients with late-stage chronic hepatitis C virus (HCV) infection, samples of various origins, including ascitic fluid and ascitic mononuclear cells (AMCs), were analyzed by the method of single-strand conformation polymorphism (SSCP). Subsequently, the major species were isolated, sequenced, and subjected to...
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