Article
Cytochrome P450 CYP2D6 genotypes: association with hair colour, Breslow thickness and melanocyte stimulating hormone receptor alleles in patients with malignant melanoma.
Pharmacogenetics - 1 Jun 1999
Strange R C, Ellison T, Ichii-Jones F, Bath J, Hoban P, Lear J T, Smith A G, Hutchinson P E, Osborne J, Bowers B, Jones P W, Fryer A A
Abstract excerpt
We previously identified associations between polymorphism in the cytochrome P450 CYP2D6 gene and outcome in several cancers. We have now examined the hypothesis that homozygosity for the mutant alleles, CYP2D6*4 and CYP2D6*3, is associated with susceptibility and outcome in malignant melanoma. Outcome was assessed by Breslow thickness. We first confirmed previous reports that these mutant alleles are associated...
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