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Article

Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2000

Hutchinson P E, Osborne J E, Lear J T, Smith A G, Bowers P W, Morris P N, Jones P W, York C, Strange R C, Fryer A A

Abstract excerpt

Calcitriol [1,25(OH)2D3], the hormonal derivative of vitamin D3, is an antiproliferative and prodifferentiation factor for several cell types, including cultured melanocytes and malignant melanoma (MM) cells. Several polymorphisms of the vitamin D receptor (VDR) gene have been described including a FokI RFLP in exon 2, BsmI, and ApaI polymorphisms in intron 8 and an adjacent TaqI RFLP in exon 9. Alterations in...

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Share to Deoxyribonucleases, Type II Site-Specific
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Share to Receptors, Calcitriol

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Source

Identifiers

PMID: 10690530

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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