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Article

Role of oncogenes in resistance and killing by cancer therapeutic agents

1 Jan 1997

Abstract excerpt

Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. One of the goals of molecular oncology is to identify the underlying mechanisms, with the hope that more effective therapies can be developed. Several mechanisms have been suggested to contribute to chemoresistance: 1) amplification or overexpression of the P-glycoprotein family of membrane...

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Identifiers

PMID: 9090498
DOI: 10.1097/00001622-199701000-00013

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