Article
The presence of at least three alleles of the ADRB3 Trp64Arg (C/T) and UCP1 -3826A/G polymorphisms is associated with protection to overweight/obesity and with higher high-density lipoprotein cholesterol levels in Caucasian-Brazilian patients with type 2 diabetes.
Metabolic syndrome and related disorders - 1 Feb 2014
Brondani Letícia A, Duarte Guilherme C K, Canani Luís H, Crispim Daisy
Abstract excerpt
BACKGROUND: We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population. METHODS: Both polymorphisms were genotyped in 1015 T2DM patients and 561 nondiabetic subjects....
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