Article
T cells facilitate Brugia malayi development in TCRalpha(null) mice.
Experimental parasitology - 1 Sept 1999
Babu S, Shultz L D, Rajan T V
Abstract excerpt
The host-parasite interactions of Brugia malayi in mice are complex and multifactorial. In order to study the role of T cells in early B. malayi development, we infected TCRalpha(null) mice, which retain a population of CD4+ TCRbeta+ cells and TCRbeta(null) mice, which lack all TCRalphabeta(+) T cells. TCRalpha(null) mice were permissive to L4 larval and adult worm development but TCRbeta(null) mice were not....
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