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Article

The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation.

Frontiers in immunology - 1 Jan 2023

Manning John Tyler, Maruyama Junki, Wanninger Timothy, Reyna Rachel A, Stevenson Heather L, Peng Bi-Hung, Mantlo Emily K, Huang Cheng, Paessler Slobodan

Abstract excerpt

Junin virus (JUNV) is a member of the Arenaviridae family of viruses and is the pathogen responsible for causing Argentine hemorrhagic fever, a potentially lethal disease endemic to Argentina. A live attenuated vaccine for human use, called Candid#1, is approved only in Argentina. Candid#1 vaccine strain of Junin virus was obtained through serial passage in mouse brain tissues followed by passage in Fetal Rhesus...

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Identifiers

PMID: 37334351
DOI: 10.3389/fimmu.2023.1172792
PMCID: PMC10272451

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The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation.PMID 37334351Read ↗

The Glycoprotein Precursor Gene of Junin Virus Determines the Virulence of the Romero Strain and the Attenuation of the Candid #1 Strain in a Representative Animal Model of Argentine Hemorrhagic FeverSemantic proximity Read ↗

Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever.Semantic proximity Read ↗

Machupo virus with mutations in the transmembrane domain and glycosylation sites is attenuated and immunogenic in animal models of Bolivian Hemorrhagic FeverSemantic proximity Read ↗

Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine.Semantic proximity Read ↗

The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome.Semantic proximity Read ↗

Substitutions in the Glycoprotein (GP) of the Candid#1 Vaccine Strain of Junin Virus Increase Dependence on Human Transferrin Receptor 1 for Entry and Destabilize the Metastable Conformation of GPSemantic proximity Read ↗

Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicitySemantic proximity Read ↗

Second-Generation Live-Attenuated Candid#1 Vaccine Virus Resists Reversion and Protects against Lethal Junín Virus Infection in Guinea PigsSemantic proximity Read ↗

The Major Determinant of Attenuation in Mice of the Candid1 Vaccine for Argentine Hemorrhagic Fever Is Located in the G2 Glycoprotein Transmembrane DomainSemantic proximity Read ↗

Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and ImmunogenicSemantic proximity Read ↗

Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPCSemantic proximity Read ↗

A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.Semantic proximity Read ↗

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