Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-PCR-dependent detection of the factor V Leiden mutation from genomic DNA using a homogeneous invader microtiter plate assay.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jun 1999

Ryan D, Nuccie B, Arvan D

Abstract excerpt

BACKGROUND: The goal of this study was to compare the Invader technology for the direct detection of the Factor V Leiden mutation from genomic DNA with a conventional polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. METHODS AND RESULTS: In the Invader assay, a specific upstream "invading" oligonucleotide and a partially overlapping downstream probe together form a specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Probes

Share to Factor V

Share to Genome, Human

Share to Mutation

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 10462628
DOI: 10.1016/s1084-8592(99)80037-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-PCR-dependent detection of the factor V Leiden mutation from genomic DNA using a homogeneous invader microtiter plate assay.PMID 10462628Read ↗

A multi-site study for detection of the factor V (Leiden) mutation from genomic DNA using a homogeneous invader microtiter plate fluorescence resonance energy transfer (FRET) assay.Semantic proximity Read ↗

Genotyping of factor V G1691A (Leiden) without the use of PCR by invasive cleavage of oligonucleotide probes.Semantic proximity Read ↗

Molecular diagnostic testing for inherited thrombophilia using Invader.Semantic proximity Read ↗

Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation.Semantic proximity Read ↗

Invader technology for DNA and RNA analysis: principles and applications.Semantic proximity Read ↗

Genotyping single-nucleotide polymorphisms by the invader assay with dual-color fluorescence polarization detection.Semantic proximity Read ↗

A microplate allele-specific oligonucleotide hybridization assay for detection of factor V Leiden.Semantic proximity Read ↗

Comparison of direct sequencing and Invader assay for Y93H mutation and response to interferon-free therapy in hepatitis C virus genotype 1b.Semantic proximity Read ↗

Analysis of the factor V Leiden mutation using the READIT Assay.Semantic proximity Read ↗

Allele-specific hybridization of lipoprotein lipase and factor-V Leiden missense mutations with direct label alkaline phosphatase-conjugated oligonucleotide probes.Semantic proximity Read ↗

Duplex PCR-RFLP for simultaneous detection of factor V Leiden and prothrombin G20210A.Semantic proximity Read ↗

Oligonucleotide ligation assay for detection of the factor V mutation (Arg506-->Gln) causing protein C resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.