Article
A trabecular meshwork glucocorticoid response (TIGR) gene mutation affects translocational processing.
Molecular vision - 23 Aug 1999
Zimmerman C C, Lingappa V R, Richards J E, Rozsa F W, Lichter P R, Polansky J R
Abstract excerpt
PURPOSE: To examine possible effects of the E323K mutation in the trabecular meshwork glucocorticoid response (TIGR) gene (also known as myocilin [MYOC]), using assays of translocational processing through the endoplasmic reticulum (ER). The E323K mutation was of particular interest, since the mutation shows a strong association with early onset open-angle glaucoma, but has a minimal predicted effect on protein...
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