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Article

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants.

Investigative ophthalmology & visual science - 1 Oct 2004

Gobeil Stéphane, Rodrigue Marc-André, Moisan Steve, Nguyen Thai D, Polansky Jon R, Morissette Jean, Raymond Vincent

Abstract excerpt

PURPOSE: To investigate mechanism(s) by which mutations in the olfactomedin domain of myocilin (MYOC), also known as the trabecular meshwork-induced glucocorticoid response (TIGR) gene, cause autosomal dominant open-angle glaucoma, the structure and properties of wild-type (WT) MYOC protein were examined, when expressed alone or simultaneously with the Q368X or K423E disease-associated polypeptides. METHODS:...

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Source

Identifiers

PMID: 15452063
DOI: 10.1167/iovs.04-0300

Genes

MYOC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants.PMID 15452063Read ↗

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