Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphism of 5,10-MTHFR reductase gene in offspring of patients with myocardial infarction.

Thrombosis and haemostasis - 1 Jul 1999

Margaglione M, Colaizzo D, Cappucci G, del Popolo A, Vecchione G, Grandone E, Di Minno G

Abstract excerpt

A family history of myocardial infarction is a major determinant of ischemic disease. A C->T677 polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified as a cause of mild hyperhomocysteinemia, a risk factor for arterial thrombosis. We have investigated the relationship between the MTHFR TT genotype and a family history of myocardial infarction in a cohort of 982 apparently healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Myocardial Infarction

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 10456448

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphism of 5,10-MTHFR reductase gene in offspring of patients with myocardial infarction.PMID 10456448Read ↗

Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarctionSemantic proximity Read ↗

Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls.Semantic proximity Read ↗

Markers of risk in young offspring with paternal history of myocardial infarction.Semantic proximity Read ↗

[Role of polymorphic variants of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene in the pathogenesis of cardiovascular diseases].Semantic proximity Read ↗

C-reactive protein in offspring is associated with the occurrence of myocardial infarction in first-degree relatives.Semantic proximity Read ↗

Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.Semantic proximity Read ↗

Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction.Semantic proximity Read ↗

Genetic factors of the hemostatic system in young patients with myocardial infarction.Semantic proximity Read ↗

C667T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene and susceptibility to myocardial infarction: A systematic review and meta-analysis.Semantic proximity Read ↗

Prothrombotic genetic risk factors in young survivors of myocardial infarction.Semantic proximity Read ↗

Prothrombotic gene variants as risk factors of acute myocardial infarction in young women.Semantic proximity Read ↗

Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.