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Article

Prothrombotic gene variants as risk factors of acute myocardial infarction in young women.

Journal of translational medicine - 21 Nov 2012

Tomaiuolo Rossella, Bellia Chiara, Caruso Antonietta, Di Fiore Rosanna, Quaranta Sandro, Noto Davide, Cefalù Angelo B, Di Micco Pierpaolo, Zarrilli Federica, Castaldo Giuseppe, Averna Maurizio R, Ciaccio Marcello

Abstract excerpt

BACKGROUND: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. METHODS: We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245...

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PMID: 23171482
DOI: 10.1186/1479-5876-10-235
PMCID: PMC3543285

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MTHFR

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