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Article

Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.

Molecular and cellular biology - 1 Sept 1999

Weil R, Sirma H, Giannini C, Kremsdorf D, Bessia C, Dargemont C, Bréchot C, Israël A

Abstract excerpt

The X protein of hepatitis B virus (HBV) is a transcriptional activator which is required for infection and may play an important role in HBV-associated hepatocarcinogenesis. It has been suggested that X acts as a nuclear coactivator or stimulates several signal transduction pathways by acting in the cytoplasm. One of these pathways leads to the nuclear translocation of NF-kappaB. A recent report indicates that X...

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Identifiers

PMID: 10454581
DOI: 10.1128/MCB.19.9.6345
PMCID: PMC84605

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.PMID 10454581Read ↗

The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction.Semantic proximity Read ↗

Biochemistry and functions of hepatitis B virus X protein.Semantic proximity Read ↗

IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2.Semantic proximity Read ↗

Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.Semantic proximity Read ↗

UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein.Semantic proximity Read ↗

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elementsSemantic proximity Read ↗

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.Semantic proximity Read ↗

Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses.Semantic proximity Read ↗

Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation.Semantic proximity Read ↗

Hepatitis B virus X protein transactivates the long terminal repeats of human immunodeficiency virus types 1 and 2.Semantic proximity Read ↗

Identification of a binding protein to the X gene promoter region of hepatitis B virus.Semantic proximity Read ↗

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