Article
Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.
The Journal of pharmacology and experimental therapeutics - 1 Sept 1999
Rasmussen E, Cipp L, Hitzemann R
Abstract excerpt
Previous studies have established that neuroleptic-induced catalepsy in mice is a highly heritable trait. The current study focuses on the detection of quantitative trait loci (QTL) for haloperidol-induced catalepsy in a BALB/cJ x LP/J F(2) intercross. One thousand thirty-seven F(2) animals were phenotyped and divided into four categories: very responsive (RR), responsive, nonresponsive, and very nonresponsive...
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