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Article

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.

Genes, chromosomes & cancer - 1 Mar 1999

van der Houven van Oordt C W, Smits R, Schouten T G, Houwing-Duistermaat J J, Williamson S L, Luz A, Meera Khan P, van der Eb A J, Breuer M L, Fodde R

Abstract excerpt

The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several...

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Source

Identifiers

PMID: 10451698
DOI: 10.1002/(sici)1098-2264(199903)24:3<191::aid-gcc3>3.0.co;2-l

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.PMID 10451698Read ↗

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