Article
A putative susceptibility locus on chromosome 18 is not a major contributor to human selective IgA deficiency: evidence from meiotic mapping of 83 multiple-case families.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1999
Vorechovský I, Blennow E, Nordenskjöld M, Webster A D, Hammarström L
Abstract excerpt
Previous reports of an association between constitutional chromosome 18 abnormalities and low levels of IgA suggested that this chromosome contains a susceptibility locus for selective IgA deficiency (IgAD), the most frequent Ig deficiency in humans. IgAD is genetically related to common variable immunodeficiency (CVID), characterized by a lack of additional isotypes. Our previous linkage analysis of 83...
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