Article
Linkage of autosomal dominant common variable immunodeficiency to chromosome 5p and evidence for locus heterogeneity.
Human genetics - 1 Apr 2003
Braig D U, Schäffer A A, Glocker E, Salzer U, Warnatz K, Peter H H, Grimbacher B
Abstract excerpt
Common variable immunodeficiency (CVID, OMIM 240500) and selective immunoglobulin A deficiency (IgAD) are the most frequent primary immunodeficiencies in humans. Of the cases with CVID/IgAD, 20%-25% are familial, but the only previous claims of linkage or association are to the HLA region on chromosome 6p. We report the results of a genome-wide scan in three multiplex families with CVID, IgAD, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.