Article

UVB-Induced Nuclear Translocation of PTEN Promotes Radiation Sensitivity of Human Malignant Glioma U87MG Cells

2020-10-16

Abstract excerpt

<title>Abstract</title> <p>Background<italic>PTEN </italic>is a tumor suppressor gene, which is often inactivated through mutation and/or deletion in diverse human tumors. In the cytoplasm, PTEN negatively regulates the phosphatidylinositol 3′ kinase (PI3K) signaling pathway, while PTEN also shuttles to the nucleus, where PTEN stabilizes genome and/or participates in DNA repairment after damage. PTEN’s subcellula...

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Literature Corpus work: ddd8c000-76a1-5aec-91c7-09d50e40441f
DOI: 10.21203/rs.3.rs-88310/v1

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