Article
Suicide, impulsive aggression, and HTR1B genotype.
Biological psychiatry - 1 Jul 2001
New A S, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever L J
Abstract excerpt
BACKGROUND: Suicidality and impulsive aggression are partially heritable, and postmortem brain studies suggest that abnormalities in serotonin 1B may be associated with suicide. Studies of serotonin 1B "knockout" mice show an increase in aggressive behavior relative to wild-type mice. METHODS: We assessed the relationship between genotype at the HTR1B locus and both suicide history and impulsive aggression in...
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