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Article

Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2003

Huang Yung-yu, Oquendo Maria A, Friedman Jill M Harkavy, Greenhill Lawrence L, Brodsky Beth, Malone Kevin M, Khait Vadim, Mann J John

Abstract excerpt

The 5-HT(1B) receptor has been implicated in several psychopathologies, including pathological aggression, alcoholism and suicide. To test these and related potential genetic relationships in a single population, the human 5-HT(1B) receptor (h5-HTR(1B)) genotype for the G861C polymorphism was determined in 394 psychiatric patients and 96 healthy volunteers. Structured clinical interviews generated DSM III-R...

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PMID: 12496953
DOI: 10.1038/sj.npp.1300000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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