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Article

Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.

The American journal of tropical medicine and hygiene - 1 Jul 1999

Mookherjee S, Howard V, Nzila-Mouanda A, Watkins W, Sibley C H

Abstract excerpt

As resistance to chloroquine spreads in sub-Saharan Africa, pyrimethamine plus sulfadoxine (PSD) is increasingly used as a first-line treatment for falciparum malaria. Populations of Plasmodium falciparum (Pf) resistant to PSD have been selected quickly in other regions. The resistance is strongly correlated with point mutations in dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), the two...

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Source

Identifiers

PMID: 10432070
DOI: 10.4269/ajtmh.1999.61.131

Genes

DHFR
PSD
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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