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Article

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.

Neurology - 22 Jul 1999

MacLeod M J, Dahiyat M T, Cumming A, Meiklejohn D, Shaw D, St Clair D

Abstract excerpt

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that...

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Source

Identifiers

PMID: 10430441
DOI: 10.1212/wnl.53.2.418

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.PMID 10430441Read ↗

Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility.Semantic proximity Read ↗

Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women.Semantic proximity Read ↗

The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans.Semantic proximity Read ↗

Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.Semantic proximity Read ↗

Importance of NOS3 genetic polymorphisms in the risk of development of ischemic stroke in the Turkish population.Semantic proximity Read ↗

Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. The GENIC Investigators.Semantic proximity Read ↗

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies.Semantic proximity Read ↗

NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors.Semantic proximity Read ↗

The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.Semantic proximity Read ↗

Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.Semantic proximity Read ↗

Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer's disease-- a meta-analysis.Semantic proximity Read ↗

Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism.Semantic proximity Read ↗

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