Article
H-ras gene amplification or mutation is not common in human primary breast cancer.
Oncology reports - 1 Jan 2000
Schondorf T, Andrack A, Niederacher D, Scharl A, Becker M, Engel H, Gohring U J
Abstract excerpt
In a clinical study we found that patients with primary node negative breast cancer whose tumors showed high expression of H-ras had a significantly better prognosis than patients whose carcinomas did not. In the present study, these tissue specimens showed no H-ras gene mutation. The rate of gene amplification was 5% and did not correlate with the level of H-ras expression. These data indicate that increased...
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