Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted inactivation of vitamin D hydroxylases in mice.

Bone - 1 Jul 1999

St-Arnaud R

Abstract excerpt

Vitamin D undergoes a first hydroxylation in the liver to generate 25-hydroxyvitamin D, then this metabolite is further hydroxylated in the kidney to yield either 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], or 24R,25-dihydroxyvitamin D[24,25(OH)2D]. The production of 1alpha,25(OH)2D is catalyzed by the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase), while the synthesis of 24,25(OH)2D is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Development
Share to Embryonic and Fetal Development
Share to Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Steroid Hydroxylases

Share to Vitamin D

Source

Identifiers

PMID: 10423037
DOI: 10.1016/s8756-3282(99)00118-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted inactivation of vitamin D hydroxylases in mice.PMID 10423037Read ↗

Targeted Inactivation of the 25-Hydroxyvitamin D3-1α-Hydroxylase Gene (CYP27B1) Creates an Animal Model of Pseudovitamin D-Deficiency Rickets*Semantic proximity Read ↗

Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D.Semantic proximity Read ↗

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null MiceSemantic proximity Read ↗

25-Hydroxyvitamin D 1α-Hydroxylase: Structure of the Mouse Gene, Chromosomal Assignment, and Developmental ExpressionSemantic proximity Read ↗

Genetic dissection of corticosteroid receptor function in mice.Semantic proximity Read ↗

Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.Semantic proximity Read ↗

Cytochrome P450-mediated metabolism of vitamin D.Semantic proximity Read ↗

Partial rescue of the phenotype in 1α-hydroxylase gene knockout mice by vitamin D3 injection.Semantic proximity Read ↗

CYP24A1 loss of function: Clinical phenotype of monoallelic and biallelic mutations.Semantic proximity Read ↗

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.Semantic proximity Read ↗

Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression.Semantic proximity Read ↗

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.