Article
A conspicuous adaptability to antibiotics in the Escherichia coli mutator strain, dnaQ49.
FEMS microbiology letters - 1 Jul 1999
Tanabe K, Kondo T, Onodera Y, Furusawa M
Abstract excerpt
By repeating the cycle of mutagenesis and selection, the Escherichia coli dnaQ49 mutator acquired high level resistance to ampicillin (30,000 micrograms ml-1), streptomycin (26,000 micrograms ml-1) and ofloxacin (3000 micrograms ml-1). Under the strong pressure of ofloxacin, dnaQ49 also followed the history of mutations in the gyrase and topoisomerase i.v. genes previously observed in clinical isolates of...
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