Article
A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs.
American journal of human genetics - 1 Aug 1999
Zhu G, Duffy D L, Eldridge A, Grace M, Mayne C, O'Gorman L, Aitken J F, Neale M C, Hayward N K, Green A C, Martin N G
Abstract excerpt
Important risk factors for melanoma are densely clustered melanocytic nevi (common moles) and mutations in the p16 (CDKN2A) gene. Nevi may be subclassified as raised or flat. In our sample, raised nevi were 27% of the total, and the two kinds had a correlation of.33. Correlations for total-nevus count (TNC) in 153 MZ and 199 DZ twin pairs were.94 and.60, respectively, which are compatible with a very-high degree...
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