Article
Heritability and gene-environment interactions for melanocytic nevus density examined in a U.K. adolescent twin study.
The Journal of investigative dermatology - 1 Aug 2001
Wachsmuth R C, Gaut R M, Barrett J H, Saunders C L, Randerson-Moor J A, Eldridge A, Martin N G, Bishop T D, Newton Bishop J A
Abstract excerpt
Risk factors for melanoma include environmental (particularly ultraviolet exposure) and genetic factors. In rare families, susceptibility to melanoma is determined by high penetrance mutations in the genes CDKN2A or CDK4, with more common, less penetrant genes also postulated. A further, potent risk factor for melanoma is the presence of large numbers of melanocytic nevi so that genes controlling nevus phenotype...
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