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Article

A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen.

Infection and immunity - 1 Aug 1999

Speert D P, Steen B, Halsey K, Kwan E

Abstract excerpt

Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon knockout (GKO) BALB/c mice to facilitate dissection of components of pathogenicity and host defense....

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Identifiers

PMID: 10417170
DOI: 10.1128/IAI.67.8.4027-4032.1999
PMCID: PMC96694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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