Article
Attenuated virulence of a Burkholderia cepacia type III secretion mutant in a murine model of infection.
Infection and immunity - 1 Mar 2003
Tomich Mladen, Griffith Adam, Herfst Christine A, Burns Jane L, Mohr Christian D
Abstract excerpt
Type III secretion systems are utilized by a number of gram-negative bacterial pathogens to deliver virulence-associated proteins into host cells. Using a PCR-based approach, we identified homologs of type III secretion genes in the gram-negative bacterium Burkholderia cepacia, an important pulmonary pathogen in immunocompromised patients and patients with cystic fibrosis. One of the genes, designated bscN,...
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