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Article

The Na+-dependent glutamate and aspartate transporter supports glutathione maintenance and survival of CHO-K1 cells.

Somatic cell and molecular genetics - 1 Nov 1998

Igo R P, Ash J F

Abstract excerpt

Glutathione synthesis, a vital cellular process, depends on L-cystine uptake by the amino acid transporter, System x-C. Here we show that a second transporter, System X-AG, is required for normal System x-C activity and glutathione maintenance by employing somatic cell mutants of CHO-K1. Uptake by System x-C in two X-AG-null mutants is significantly lower than that of CHO-K1, either under control conditions or...

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PMID: 10763412
DOI: 10.1023/a:1024438423899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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