Article
Conformational compatibility as a basis of differential affinities of tachykinins for the neurokinin-1 receptor.
Biochemistry - 19 Dec 1995
Huang R R, Huang D, Strader C D, Fong T M
Abstract excerpt
The neurokinin-1 receptor is characterized by sub-nanomolar affinity for substance P and 30-100 nM affinity for other substance P-related peptides, including neurokinin B and septide. We have characterized a neurokinin-1 receptor mutant containing a Y216A substitution in the fifth transmembrane s...
Topics
- Amino Acid Sequence
- Humans
- Kinetics
- Ligands
- Models, Chemical
- Molecular Conformation
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Neurokinin-1 Receptor Antagonists
- Receptors, Neurokinin-1
- Sequence Analysis, DNA
- Structure-Activity Relationship
- Substance P
- Tachykinins