Article
Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.
Genomics - 15 Oct 1998
Zhao N, Lai F, Fernald A A, Eisenbart J D, Espinosa R, Wang P W, Le Beau M M
Abstract excerpt
The transition from metaphase to anaphase and exit from mitosis involve the degradation of active cyclin B-CDC2 complexes by ubiquitin-mediated proteolysis. The anaphase-promoting complex (APC) catalyzes the formation of cyclin B-ubiquitin conjugates, thereby targeting cyclin B for degradation. T...
Topics
- Amino Acid Sequence
- Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Blotting, Northern
- Cell Cycle Proteins
- Chromosomes, Human, Pair 5
- Cloning, Molecular
- Genes, Tumor Suppressor
- Humans
- Leukemia, Myeloid
- Molecular Sequence Data
- Mutation
- Proteins
- Saccharomyces cerevisiae Proteins