Article
Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus.
Journal of the American Society of Nephrology : JASN - 1 Jul 1999
Nannipieri M, Penno G, Pucci L, Colhoun H, Motti C, Bertacca A, Rizzo L, De Giorgio L, Zerbini G, Mangili R, Navalesi R
Abstract excerpt
Approximately 30% of diabetic patients develop nephropathy, the appearance of which is partially under genetic control. Atrial natriuretic peptide (ANP) has associated physiologic effects on the kidney. This study was conducted to examine the relationship between a newly identified and known polymorphism at the pronatriodilatin (PND) gene locus and renal involvement in type 1 diabetic subjects. Of 454 type 1...
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