Article
Allele and antigen-specific treatment of rheumatoid arthritis: a double blind, placebo controlled phase 1 trial.
The Journal of rheumatology - 1 Mar 2003
Kavanaugh Arthur, Genovese Mark, Baughman Jan, Kivitz Alan, Bulpitt Ken, Olsen Nancy, Weisman Michael, Matteson Eric, Furst Daniel, van Vollenhoven Ronald, Anderson James, Cohen Stanley, Wei Nathan, Meijerink Jan, Jacobs Cindy, Mocci Simonetta
Abstract excerpt
OBJECTIVE: Human cartilage glycoprotein 39 (HC gp-39) appears to be a relevant autoantigen in patients with rheumatoid arthritis (RA). Administration of major histocompatibility complex (MHC) Class II complexed antigens without requisite costimulatory signals can induce immunologic tolerance. We evaluated the safety, pharmacokinetics, and preliminary efficacy of AG4263 in patients with RA. AG4263 is a soluble...
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