Article
Lymphoma development in Sjögren's syndrome: novel p53 mutations.
Arthritis and rheumatism - 1 Jul 1999
Tapinos N I, Polihronis M, Moutsopoulos H M
Abstract excerpt
OBJECTIVE: Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltrations of the exocrine glands. Disease progression may lead to uncontrolled clonal proliferation of B lymphocytes and development of lymphoma. This study was undertaken to examine the possible involvement of the cell cycle checkpoint genes p53 and p21 in the pathophysiology of the syndrome. METHODS: Protein...
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