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Article

Identification of the erythropoietin receptor domain required for calcium channel activation.

The Journal of biological chemistry - 16 Jul 1999

Miller B A, Barber D L, Bell L L, Beattie B K, Zhang M Y, Neel B G, Yoakim M, Rothblum L I, Cheung J Y

Abstract excerpt

Erythropoietin (Epo) activates a voltage-independent Ca2+ channel that is dependent on tyrosine phosphorylation. To identify the domain(s) of the Epo receptor (Epo-R) required for Epo-induced Ca2+ influx, Chinese hamster ovary (CHO) cells were transfected with wild-type or mutant Epo receptors subcloned into pTracer-cytomegalovirus vector. This vector contains an SV40 early promoter, which drives expression of...

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PMID: 10400674
DOI: 10.1074/jbc.274.29.20465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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