Article
Imprinted methylation and its effect on expression of the mouse Zfp127 gene.
Gene - 8 Jul 1999
Hershko A, Razin A, Shemer R
Abstract excerpt
The Zfp127 gene is located on mouse chromosome 7 in an imprinted region that is homologous to the 2-Mb Prader-Willi and Angelman Syndromes region on human chromosome 15q11-q13. Here, we show that the gene is differentially methylated, the maternal allele being methylated and the paternal allele being unmethylated. This maternal methylation is established promptly after fertilization prior to syngamy. We also...
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