Article
Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.
BMC genomics - 21 Apr 2011
Wang Qianwei, Chow Jacqueline, Hong Jenny, Smith Anne Ferguson, Moreno Carol, Seaby Peter, Vrana Paul, Miri Kamelia, Tak Joon, Chung Eu Ddeum, Mastromonaco Gabriela, Caniggia Isabella, Varmuza Susannah
Abstract excerpt
BACKGROUND: The proximal region of murine Chr 2 has long been known to harbour one or more imprinted genes from classic genetic studies involving reciprocal translocations. No imprinted gene had been identified from this region until our study demonstrated that the PcG gene Sfmbt2 is expressed from the paternally inherited allele in early embryos and extraembryonic tissues. Imprinted genes generally reside in...
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