Article
Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder.
Molecular psychiatry - 1 May 1999
Jacobsen N J, Franks E K, Owen M J, Craddock N J
Abstract excerpt
Evidence for the involvement of genetic factors in the pathogenesis of bipolar affective disorder is now well established. However, the mode of inheritance is non-mendelian and this makes the identification of susceptibility loci difficult. A short-cut to localisation of a disease gene for an oligogenic/multifactorial disorder such as bipolar disorder may come from observation of cosegregation with a monogenic...
Topics
- Adult
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 12
- DNA Mutational Analysis
- Darier Disease
- Exons
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Phospholipases A
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length