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Article

mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999

Hu G, Gershon P D, Hodel A E, Quiocho F A

Abstract excerpt

We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine, N3-methylcytosine) and their unmethylated counterparts, or nucleoside N7-methylguanosine. Together with solution affinity studies and previous...

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Identifiers

PMID: 10377383
DOI: 10.1073/pnas.96.13.7149
PMCID: PMC22034

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