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Article

Analysis of flavivirus NS5 methyltransferase cap binding.

Journal of molecular biology - 6 Feb 2009

Geiss Brian J, Thompson Aaron A, Andrews Andrew J, Sons Robert L, Gari Hamid H, Keenan Susan M, Peersen Olve B

Abstract excerpt

The flavivirus 2'-O-nucleoside N-terminal RNA methyltransferase (MTase) enzyme is responsible for methylating the viral RNA cap structure. To increase our understanding of the mechanism of viral RNA cap binding we performed a detailed structural and biochemical characterization of the guanosine cap-binding pocket of the dengue (DEN) and yellow fever (YF) virus MTase enzymes. We solved an improved 2.1 A resolution...

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Share to Binding Sites
Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine Triphosphate

Share to Hydrogen Bonding

Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 19101564
DOI: 10.1016/j.jmb.2008.11.058
PMCID: PMC2680092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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