Article
mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo.
Journal of virology - 1 Mar 2014
Ma Yuanmei, Wei Yongwei, Zhang Xiaodong, Zhang Yu, Cai Hui, Zhu Yang, Shilo Konstantin, Oglesbee Michael, Krakowka Steven, Whelan Sean P J, Li Jianrong
Abstract excerpt
UNLABELLED: One role of mRNA cap guanine-N-7 (G-N-7) methylation is to facilitate the efficient translation of mRNA. The role of mRNA cap ribose 2'-O methylation is enigmatic, although recent work has implicated this as a signature to avoid detection of RNA by the innate immune system (S. Daffis, K. J. Szretter, J. Schriewer, J. Q. Li, S. Youn, J. Errett, T. Y. Lin, S. Schneller, R. Zust, H. P. Dong, V. Thiel, G....
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