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Article

Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer.

Cancer - 15 Jun 1999

Heinimann K, Scott R J, Buerstedde J M, Weber W, Siebold K, Attenhofer M, Müller H, Dobbie Z

Abstract excerpt

BACKGROUND: Hereditary nonpolyposis colorectal cancer (HNPCC) is linked genetically to mutations in DNA mismatch repair (MMR) genes. Because a deficiency in MMR does not predict a specific phenotype, the original selection criteria may be too restrictive in identifying additional families. The current study was performed to determine whether a relaxation of the Amsterdam criteria (AC) could be applied to identify...

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Identifiers

PMID: 10375096
DOI: 10.1002/(sici)1097-0142(19990615)85:12<2512::aid-cncr4>3.0.co;2-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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